Dimerization dictates the message
نویسندگان
چکیده
منابع مشابه
Dimerization dictates the message
The different members of the human type I interferon (IFN) family can induce distinct cellular responses, even though they all bind to the same cell surface receptor. All IFNs evoke a potent antiviral response, for example , but IFN is far more effective than IFN␣2 at inhibiting cell proliferation. Such " functional plasticity " is a common feature of cytokine signaling, but the mechanisms by ...
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A growing body of evidence suggests that GPCRs exist and function as dimers or higher oligomers. The evidence for GPCR dimerization comes from biochemical, biophysical and functional studies. In addition, researchers have shown the occurrence of heterodimerization between different members of the GPCR family. Two receptors can interact with each other to make a dimer through their extracellular...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2015
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.2094if